Cebpb^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Cebpb^tm1Aki
• Name: CCAAT/enhancer binding protein beta; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:4362073
• Synonyms: C/ebpb^M20A
• Gene: Cebpb Location: Chr2:167530835-167532338 bp, + strand Genetic Position: Chr2, 87.58 cM
• Alliance: Cebpb^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153025
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector replaced an ATG codon for methionine 20 of the gene corresponding to the start site for the 34-kDa liver-enriched transcriptional activation protein (LAP) to a GCG codon for alanine followed by loxP franked neo cassette. Western blot analysis in LPS stimulated peritoneal macrophages shows abolished expression of 34-kDa LAP isoform. 38-kDa Full length LAP isoform and 20-kDa liver-enriched transcription inhibitory protein (LIP) isoform are expressed at normal level. (J:153025)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cebpb Mutation: 23 strains or lines available

References

• Original: J:153025 Uematsu S, et al., The C/EBP beta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing. J Immunol. 2007 Oct 15;179(8):5378-86
• All: 3 reference(s)