Tg(Gfap-gp120)2Lms
Transgene Detail

Summary

• Symbol: Tg(Gfap-gp120)2Lms
• Name: transgene insertion 2, Lennart Mucke
• MGI ID: MGI:4361816
• Transgene: Tg(Gfap-gp120)2Lms Location: unknown
• Alliance: Tg(Gfap-gp120)2Lms page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The env gene from the LAV strtain of HIV-1 was truncated to encode gp120 amino acids 1-509 and inserted in exon 1 of a modified murine Gfap gene. Five lines (2, 3,10, 16, 37) were established which varied in level of expression. Level of expression did not correlate with transgene copy number. This is a high expressor line. (J:146427)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:146427 Toggas SM, et al., Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature. 1994 Jan 13;367(6459):188-93
• All: 2 reference(s)