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Tg(MMTV-Erbb2*,-cre)1Mul
Transgene Detail
Summary
Symbol: Tg(MMTV-Erbb2*,-cre)1Mul
Name: transgene insertion 1, William J Muller
MGI ID: MGI:4361017
Synonyms: MMTV-Neu-IRES-CRE, MMTV-NeuNDL2-5-IRES-Cre, MMTV-NIC, NIC
Transgene: Tg(MMTV-Erbb2*,-cre)1Mul  Location: unknown  
Alliance: Tg(MMTV-Erbb2*,-cre)1Mul page
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence, Recombinase)
Mutation:    Insertion
 
Tg(MMTV-Erbb2*,-cre)1Mul expresses 1 gene
 
Tg(MMTV-Erbb2*,-cre)1Mul expression driven by 1 gene
 
Mutation detailsA transgene was generated where an activated Erbb2 (Neu, oncogenic form NDL2-5) and cre recombinase (coupled by an internal ribosomal entry site (IRES)) are under control of the mammalian mammary tumor virus promoter (MMTV). (J:133325)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: MMTV (virus)
Summary of all recombinase alleles driven by MMTV.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Tumor Data
List all tumor models in MMHCdb carrying Tg(MMTV-Erbb2*,-cre)1Mul
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:133325 Ursini-Siegel J, et al., ShcA signalling is essential for tumour progression in mouse models of human breast cancer. EMBO J. 2008 Mar 19;27(6):910-20
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory