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Tg(RBP3-ELOVL4*)2Kzh
Transgene Detail
Nomenclature
Symbol: Tg(RBP3-ELOVL4*)2Kzh
Name: transgene insertion 2, Kang Zhang
MGI ID: MGI:4360792
Synonyms: tg2
Transgene: Tg(RBP3-ELOVL4*)2Kzh  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(RBP3-ELOVL4*)2Kzh expresses 1 gene
 
Mutation detailsThe human promoter was used to drive photoreceptor-specific expression of a human cDNA with a deletion of AACTT at position 790 to 794 found in patients with Stargardt-like macular dystrophy. Three lines were created (lines 1, 2, and 3) with 0.6, 3.3, and 5.3 times the level of endogenous gene expression, respectively. (J:97173)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:97173 Karan G, et al., Lipofuscin accumulation, abnormal electrophysiology, and photoreceptor degeneration in mutant ELOVL4 transgenic mice: a model for macular degeneration. Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4164-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory