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Targeted Allele Detail
Symbol: Pak4tm2.2Amin
Name: p21 (RAC1) activated kinase 4; targeted mutation 2.2, Audrey Minden
MGI ID: MGI:4360338
Synonyms: Pak4delta
Gene: Pak4  Location: Chr7:28558819-28598184 bp, - strand  Genetic Position: Chr7, 16.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:152821
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsGerm line, cre mediated recombination removed exons 2 through 4 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on mouse embyonic fibroblast extracts. (J:152821)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pak4 Mutation:  65 strains or lines available
Original:  J:152821 Tian Y, et al., Essential role for the Pak4 protein kinase in extraembryonic tissue development and vessel formation. Mech Dev. 2009 Aug-Sep;126(8-9):710-20
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory