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Angptl2tm1Yo
Targeted Allele Detail
Nomenclature
Symbol: Angptl2tm1Yo
Name: angiopoietin-like 2; targeted mutation 1, Yuichi Oike
MGI ID: MGI:4359444
Gene: Angptl2  Location: Chr2:33216069-33247717 bp, + strand  Genetic Position: Chr2, 22.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:152387
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 2 including the ATG transcription start site was replaced with a lacZ reporter construct and a floxed neomycin cassette. Gene inactivation was confirmed by Northern blot analysis on homozygous skin extracts. (J:152387)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Angptl2 Mutation:  9 strains or lines available
References
Original:  J:152387 Tabata M, et al., Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. Cell Metab. 2009 Sep;10(3):178-88
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory