Gpbar1^tm1.1Auw
Targeted Allele Detail

Summary

• Symbol: Gpbar1^tm1.1Auw
• Name: G protein-coupled bile acid receptor 1; targeted mutation 1.1, Johan Auwerx
• MGI ID: MGI:4359278
• Synonyms: TGR5^L2
• Gene: Gpbar1 Location: Chr1:74317709-74318783 bp, + strand Genetic Position: Chr1, 38.53 cM
• Alliance: Gpbar1^tm1.1Auw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152388
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a floxed and frt-flanked neo cassette was inserted downstream of exon 1. Flp mediated recombination removed the neo cassette leaving exon 1 floxed. (J:152388)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpbar1 Mutation: 33 strains or lines available

References

• Original: J:152388 Thomas C, et al., TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab. 2009 Sep;10(3):167-77
• All: 7 reference(s)