Gpbar1tm1.1Auw
Targeted Allele Detail
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Symbol: |
Gpbar1tm1.1Auw |
Name: |
G protein-coupled bile acid receptor 1; targeted mutation 1.1, Johan Auwerx |
MGI ID: |
MGI:4359278 |
Synonyms: |
TGR5L2 |
Gene: |
Gpbar1 Location: Chr1:74317709-74318783 bp, + strand Genetic Position: Chr1, 38.53 cM
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Alliance: |
Gpbar1tm1.1Auw page
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Germline Transmission: |
Earliest citation of germline transmission:
J:152388
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129/Sv
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A loxP site was inserted upstream of exon 1 and a floxed and frt-flanked neo cassette was inserted downstream of exon 1. Flp mediated recombination removed the neo cassette leaving exon 1 floxed.
(J:152388)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gpbar1 Mutation: |
28 strains or lines available
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Original: |
J:152388 Thomas C, et al., TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab. 2009 Sep;10(3):167-77 |
All: |
7 reference(s) |
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