Lat^tm5.1Mal
Targeted Allele Detail

Summary

• Symbol: Lat^tm5.1Mal
• Name: linker for activation of T cells; targeted mutation 5.1, Bernard Malissen
• MGI ID: MGI:4357969
• Synonyms: B6-Lat null, Lat tm5mal, Lat^tm5Mal
• Gene: Lat Location: Chr7:125962996-125968742 bp, - strand Genetic Position: Chr7, 69.01 cM
• Alliance: Lat^tm5.1Mal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152363
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Deletion of exons 1 to 12 occurred by replacement with an autodeleting cre+neo cassette (loxP site, the mouse Ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1) promoter, the cre recombinase gene, a neomycin resistance gene cassette, and a second loxP site). The whole coding region was removed. (J:152363)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lat Mutation: 9 strains or lines available

References

• Original: J:152363 Malissen M, Personal Communication concerning Lat null mice. Personal Communication. 2009
• All: 1 reference(s)