Aopep^Gt(GT411)Lmf
Gene trapped Allele Detail

Summary

• Symbol: Aopep^Gt(GT411)Lmf
• Name: aminopeptidase O; gene trap GT411, Lesley M Forrester
• MGI ID: MGI:4357693
• Synonyms: ApO^Gt411For
• Gene: Aopep Location: Chr13:63112707-63473910 bp, + strand Genetic Position: Chr13, 32.8 cM, cytoband B3
• Alliance: Aopep^Gt(GT411)Lmf page

Mutation origin

• Mutant Cell Line: GT411
• Germline Transmission: Earliest citation of germline transmission: J:152135
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Reporter)
• Mutation: Insertion of gene trap vector Vector Type: gene trap
• Mutation details: A gene trap vector containing a beta-geo cassette inserted into the 3 prime end of the gene between two introns that encode the armadillo repeat region. A fusion gene product resulted where the last 46 amino acids of the endogenous gene product was replaced with betageo. Northern blot analysis on homozygote E11.5 embryos indicate only the fusion gene product is expressed. LacZ expression was detected throughout the vasculature of embryonic and adult heterozygote mice. (J:152135)

Expression

In Mice Carrying this Mutation:

17 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aopep Mutation: 62 strains or lines available

References

• Original: J:152135 Axton R, et al., Aminopeptidase O contains a functional nucleolar localization signal and is implicated in vascular biology. J Cell Biochem. 2008 Mar 1;103(4):1171-82
• All: 1 reference(s)