Tg(Ins1-luc)VUPwrs
Transgene Detail

Summary

• Symbol: Tg(Ins1-luc)VUPwrs
• Name: transgene insertion VU, Alvin Powers
• MGI ID: MGI:4357680
• Synonyms: MIP-Luc-VU
• Transgene: Tg(Ins1-luc)VUPwrs Location: unknown
• Alliance: Tg(Ins1-luc)VUPwrs page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The MIP-luc transgenic construct was designed with the 9.2 kb mouse insulin I promoter (MIP or Ins1) and a luciferase (luc) optical reporter cDNA gene (with a rabbit beta-globin intronic and polyA sequences and 3' non-transgenic region flanking the luc fragment on each side to stabilize the transgene). This transgene was injected into FVB/N embryos. Mice from founder line "VU" (specifically 43-8 (line 5)) exhibited the highest and most consistent luciferase expression over the pancreatic region and were found to have approximately three copies. (J:152066)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:152066 Virostko J, et al., Bioluminescence Imaging in Mouse Models Quantifies beta Cell Mass in the Pancreas and After Islet Transplantation. Mol Imaging Biol. 2010 Jan-Feb;2(1):42-53
• All: 4 reference(s)