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Lrrk2tm1.1Shn
Targeted Allele Detail
Nomenclature
Symbol: Lrrk2tm1.1Shn
Name: leucine-rich repeat kinase 2; targeted mutation 1.1, Jie Shen
MGI ID: MGI:4356349
Synonyms: Lrrk2R1441C
Gene: Lrrk2  Location: Chr15:91557378-91700323 bp, + strand  Genetic Position: Chr15, 46.07 cM, cytoband F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:151944
Parent Cell Line:  MKV6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129)F1
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 31 was replaced with one in which nucleotide substitutions led to the amino acid substitution of cysteine for arginine at position 1441 (R1441C), mimicking a mutation found in xome Parkinson's disease patients. A floxed neo cassette was inserted downstream of the modified exon and removed by transient cre expression in ES cells. (J:151944)
Generation of the Lrrk2tm1.1Shn allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Lrrk2 Mutation:  105 strains or lines available
References
Original:  J:151944 Tong Y, et al., R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14622-7
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory