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Atp2b2Obv
Chemically induced Allele Detail
Nomenclature
Symbol: Atp2b2Obv
Name: ATPase, Ca++ transporting, plasma membrane 2; oblivion
MGI ID: MGI:4355879
Synonyms: DEA14, Obl
Gene: Atp2b2  Location: Chr6:113743831-114042613 bp, - strand  Genetic Position: Chr6, 52.85 cM
Mutation
origin
Strain of Origin:  C3HeB/FeJ
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsENU mutagenesis created a C to T transition at position 2630 that results in an amino acid substitution of phenylalanine for serine at position 877 (S877F). This mutation occurs in transmembrane domain 6 of the PMCA2 pump, the resident calcium pump of the hair cell stereocilia. (J:151733)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atp2b2 Mutation:  16 strains or lines available
Notes
This mutant fails to compliment Atp2b2dfw (J:151733).
References
Original:  J:151733 Spiden SL, et al., The novel mouse mutation Oblivion inactivates the PMCA2 pump and causes progressive hearing loss. PLoS Genet. 2008 Oct;4(10):e1000238
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory