Gpr183^tm1.1Rbr
Targeted Allele Detail

Summary

• Symbol: Gpr183^tm1.1Rbr
• Name: G protein-coupled receptor 183; targeted mutation 1.1, Robert Brink
• MGI ID: MGI:4355831
• Gene: Gpr183 Location: Chr14:122189963-122202607 bp, - strand Genetic Position: Chr14, 65.86 cM
• Alliance: Gpr183^tm1.1Rbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151883
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an frt flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Germ line, flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:151883)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr183 Mutation: 27 strains or lines available

References

• Original: J:151883 Gatto D, et al., Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. Immunity. 2009 Aug 21;31(2):259-69
• All: 3 reference(s)