Ifnb1^tm1.2Lien
Targeted Allele Detail

Summary

• Symbol: Ifnb1^tm1.2Lien
• Name: interferon beta 1, fibroblast; targeted mutation 1.2, Stefan Lienenklaus
• MGI ID: MGI:4355681
• Synonyms: ^deltabeta-luc, IFN-B^{delta beta-luc}, IFN-B^deltabeta-luc
• Gene: Ifnb1 Location: Chr4:88440262-88441011 bp, - strand Genetic Position: Chr4, 41.91 cM
• Alliance: Ifnb1^tm1.2Lien page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151854
• Parent Cell Line: BALB/c-I (ES Cell)
• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Intragenic deletion
• Mutation details: Founder mice derived from BALB/c ES cells carrying the Ifnb1^tm1.2Lien mutation were crossed with K14-cre transgenic mice to remove the coding exon from the germline and bring the reporter construct under the control of the endogenous promoter. Reporter expression was detected in numerous tissues after viral infection. (J:151854)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ifnb1 Mutation: 20 strains or lines available

References

• Original: J:151854 Lienenklaus S, et al., Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo. J Immunol. 2009 Sep 1;183(5):3229-36
• All: 12 reference(s)