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Trp63tm1.1Elrf
Targeted Allele Detail
Nomenclature
Symbol: Trp63tm1.1Elrf
Name: transformation related protein 63; targeted mutation 1.1, Elsa R Flores
MGI ID: MGI:4355528
Synonyms: TAp63-
Gene: Trp63  Location: Chr16:25683763-25892102 bp, + strand  Genetic Position: Chr16, 17.37 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:151638
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Modified isoform(s), Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted into intron 1 and an FRT site flanked neomycin resistance gene cassette and loxP site were inserted into intron 2. Exon 2, used for the TA isoforms, and the neo cassette were deleted through cre-mediated recombination. The absence of protein expression was confirmed by western blot analysis on keratinocyte extracts. This allele specifically knocks out the TA (trans activation domain) isoforms and leaves the deltaN isoform intact. (J:151638)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp63 Mutation:  29 strains or lines available
References
Original:  J:151638 Su X, et al., TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell. 2009 Jul 2;5(1):64-75
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory