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Klk4tm1.1Jpsi
Targeted Allele Detail
Nomenclature
Symbol: Klk4tm1.1Jpsi
Name: kallikrein related-peptidase 4 (prostase, enamel matrix, prostate); targeted mutation 1.1, James P Simmer
MGI ID: MGI:4355346
Synonyms: Klk4lacZ
Gene: Klk4  Location: Chr7:43530584-43535228 bp, + strand  Genetic Position: Chr7, 28.35 cM
Abnormal dental enamel of Klk4tm1.1Jpsi/Klk4tm1.1Jpsi incisors

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:151626
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe genomic sequence spanning the initiation codon in exon 2 through exon 6 was replaced with an NLS-lacZ and floxed neo cassette. The neo cassette was subsequently removed by germ line, cre mediated recombination. This allele lacks the entire coding region. (J:151626)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Klk4 Mutation:  15 strains or lines available
References
Original:  J:151626 Simmer JP, et al., Hypomaturation enamel defects in Klk4 knockout/LacZ knockin mice. J Biol Chem. 2009 Jul 10;284(28):19110-21
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory