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Tg(Prrx1-cre/ERT2,-EGFP)1Smkm
Transgene Detail
Nomenclature
Symbol: Tg(Prrx1-cre/ERT2,-EGFP)1Smkm
Name: transgene insertion 1, Shunichi Murakami
MGI ID: MGI:4355342
Synonyms: Prx1CreER-GFP
Transgene: Tg(Prrx1-cre/ERT2,-EGFP)1Smkm  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsThe cre/ERT2 cDNA was cloned downstream of a 2.4 kb Prrx1 promoter. cDNA encoding an IRES-EGFP was inserted downstream of the cre/ERT2 sequence. This construct was injected into fertilized oocytes and 3 founders that expressed the transgene in the limbs were identified. Crosses to Rosa26-lacZ reporter mice identified two lines which had intense X-gal staining upon induction with tamoxifen. One line was chosen for further analysis. (J:151681)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Prrx1     Summary of all recombinase alleles driven by Prrx1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:151681 Kawanami A, et al., Mice expressing GFP and CreER in osteochondro progenitor cells in the periosteum. Biochem Biophys Res Commun. 2009 Aug 28;386(3):477-82
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory