Ptprc^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ptprc^m1Btlr
• Name: protein tyrosine phosphatase receptor type C; mutation 1, Bruce Beutler
• MGI ID: MGI:4355241
• Synonyms: belittle
• Gene: Ptprc Location: Chr1:137990599-138103446 bp, - strand Genetic Position: Chr1, 60.73 cM
• Alliance: Ptprc^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to T transversion at position 74078 of the genomic DNA sequence (Genbank genomic region NC_000067 for linear genomic DNA sequence of Ptprc). The mutated residue corresponds to nucleotide 1407 and nucleotide 990, respectively, in the cDNA sequences of Ptprc isoform 1 (NM_001111316) and isoform 2 (NM_011210). The mutation converts lysine 422 (isoform 1) or 283 (isoform 2) of the CD45 protein to a stop. (J:152064)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptprc Mutation: 188 strains or lines available

References

• Original: J:152064 Siggs OM, et al., Record for belittle, updated 17 Aug 2009 (Accessed 3 September 2009). MGI Direct Data Submission. 2009
• All: 2 reference(s)