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Targeted Allele Detail
Symbol: Atrtm1Ofc
Name: ataxia telangiectasia and Rad3 related; targeted mutation 1, Oscar Fernandez-Capetillo
MGI ID: MGI:4355008
Synonyms: ATRS, ATRseckel
Gene: Atr  Location: Chr9:95857597-95951781 bp, + strand  Genetic Position: Chr9, 50.27 cM, cytoband E4
Germline Transmission:  Earliest citation of germline transmission: J:151542
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion, Single point mutation
Mutation detailsExons 8 through 10 were replaced with the corresponding human sequences. In addition, exon 9 contains an A to G transition that mimicks the mutation found in patients with Seckel syndrome. This mutation results in the skipping of this exon through abnormal splicing. (J:151542)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 25 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atr Mutation:  85 strains or lines available
Original:  J:151542 Murga M, et al., A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat Genet. 2009 Aug;41(8):891-8
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory