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Tg(TcraA1,TcrbA1)1Alm
Transgene Detail
Summary
Symbol: Tg(TcraA1,TcrbA1)1Alm
Name: transgene insertion 1, Andrew Mellor
MGI ID: MGI:4354497
Synonyms: A1, A1(M), A1 TCR-transgenic
Transgene: Tg(TcraA1,TcrbA1)1Alm  Location: unknown  
Alliance: Tg(TcraA1,TcrbA1)1Alm page
Transgene
origin
Strain of Origin:  CBA/Ca
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(TcraA1,TcrbA1)1Alm expresses 2 genes
 
Mutation detailsThe TCR alpha- and beta-chain from the A1 CD41 T cell genomic clone that had been isolated from CBA/Ca mice was used to make constructs to generate transgenic mice. The A1 clone recognizes the minor histocompatibility Ag H-Y, which is present in male mice but absent in female mice, in the context of H2-Ek. (J:94036)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:94036 Zelenika D, et al., Rejection of H-Y disparate skin grafts by monospecific CD4+ Th1 and Th2 cells: no requirement for CD8+ T cells or B cells. J Immunol. 1998 Aug 15;161(4):1868-74
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/30/2025
MGI 6.24
The Jackson Laboratory