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Targeted Allele Detail
Symbol: Fgf21tm1.1Djm
Name: fibroblast growth factor 21; targeted mutation 1.1, David J Mangelsdorf
MGI ID: MGI:4354163
Gene: Fgf21  Location: Chr7:45613886-45615490 bp, - strand  Genetic Position: Chr7, 29.38 cM, cytoband B2
Germline Transmission:  Earliest citation of germline transmission: J:150831
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsGermline, cre mediated recombination removed exons 1 through 3. The absence of transcript expression was confirmed by RT-PCR or QPCR on liver extracts. The absence of plasma Fgf21 concentrations in fasted mice confirmed the lack of protein expression. (J:150831)
Generation of the Fgf21tm1Djm and Fgf21tm1.1Djm alleles
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fgf21 Mutation:  15 strains or lines available
Original:  J:150831 Potthoff MJ, et al., FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10853-8
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory