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Chemically induced Allele Detail
Symbol: Srrrgsc1872
Name: serine racemase; RIKEN Genomic Sciences Center (GSC), 1872
MGI ID: MGI:4354162
Synonyms: SrrY269*
Gene: Srr  Location: Chr11:74906509-74925948 bp, - strand  Genetic Position: Chr11, 45.76 cM, cytoband B4
Strain of Origin:  C57BL/6JJcl
Project Collection: RIKEN GSC ENU Project
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsA T to A transversion was induced at the start of exon 9 resulting in a nonsense mutation (Tyr269Stop). Western blot analysis indicated absence of protein expression in the brains of homozygous mice. D-serine production assays indicated absence of protein activity in preparations from whole brain, hippocampus, and frontal cortex from homozygous mice. (J:151337)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Srr Mutation:  17 strains or lines available
Original:  J:151337 Labrie V, et al., Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model. Hum Mol Genet. 2009 Sep 1;18(17):3227-43
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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