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Chemically induced Allele Detail
Symbol: Srrrgsc1872
Name: serine racemase; RIKEN Genomic Sciences Center (GSC), 1872
MGI ID: MGI:4354162
Synonyms: Rgsc01872, Srrochre269, SrrY269*
Gene: Srr  Location: Chr11:74906509-74925948 bp, - strand  Genetic Position: Chr11, 45.76 cM, cytoband B4
Strain of Origin:  C57BL/6JJcl
Project Collection: RIKEN GSC ENU Project
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsA T to A transversion was induced at the start of exon 9 resulting in a nonsense mutation (Tyr269Stop). Western blot analysis indicated absence of protein expression in the brains of homozygous mice. D-serine production assays indicated absence of protein activity in preparations from whole brain, hippocampus, and frontal cortex from homozygous mice. (J:151337)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Srr Mutation:  26 strains or lines available
Original:  J:151337 Labrie V, et al., Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model. Hum Mol Genet. 2009 Sep 1;18(17):3227-43
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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