Rp1l1^tm1Jnz
Targeted Allele Detail

Summary

• Symbol: Rp1l1^tm1Jnz
• Name: retinitis pigmentosa 1 homolog like 1; targeted mutation 1, Jian Zuo
• MGI ID: MGI:4354082
• Gene: Rp1l1 Location: Chr14:64229880-64270955 bp, + strand Genetic Position: Chr14, 33.34 cM
• Alliance: Rp1l1^tm1Jnz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151463
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 2, 3 and part of exon 4, which encode the translation start site, the conserved DCX tandem repeat and the RP1D domain, were replaced with a floxed neomycin cassette. Gene inactivation was confirmed by no protein detected in immunoblot or immunohistochemical analysis of the retina. (J:151463)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rp1l1 Mutation: 78 strains or lines available

References

• Original: J:151463 Yamashita T, et al., Essential and synergistic roles of RP1 and RP1L1 in rod photoreceptor axoneme and retinitis pigmentosa. J Neurosci. 2009 Aug 5;29(31):9748-60
• All: 3 reference(s)