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Mto1Gt(G019A03)Wrst
Gene trapped Allele Detail
Nomenclature
Symbol: Mto1Gt(G019A03)Wrst
Name: mitochondrial tRNA translation optimization 1; gene trap G019A03, German Gene Trap Consortium
MGI ID: MGI:4336382
Gene: Mto1  Location: Chr9:78447870-78474165 bp, + strand  Genetic Position: Chr9, 43.65 cM, cytoband E1
Mutation
origin
Mutant Cell Line:  G019A03
Germline Transmission:  Earliest citation of germline transmission: J:223246
Parent Cell Line:  TBV2 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Gene trapped (Hypomorph)
Mutation:    Insertion of gene trap vector     Vector: U3CEO     Vector Type: secretory trap
 
Mutation detailsTrapped gene association determined by genome coordinate overlap and strand. The gene trap vector U3CEO inserted into intron 6 of Mto1. Quantitative RT-PCR analysis of mRNA levels in heart from homozygotes indicate a 63% reduction compared to controls, indicating this is a hypomorphic allele. (J:223246)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mto1 Mutation:  11 strains or lines available
References
Original:  J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory