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Gene trapped Allele Detail
Symbol: Prpf3Gt(RRO284)Byg
Name: pre-mRNA processing factor 3; gene trap RRO284, BayGenomics
MGI ID: MGI:4329457
Gene: Prpf3  Location: Chr3:95830124-95855885 bp, - strand  Genetic Position: Chr3, 41.25 cM, cytoband F2
Mutant Cell Line:  RRO284
Germline Transmission:  Earliest citation of germline transmission: J:141780
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector     Vector: pGT2Lxf     Vector Type: gene trap
Mutation detailsThe gene trap vector pGT2lxf inserted after exon 2. Southern blot analysis indicates that this insertion results in deletion of a significant portion of the gene including exons 3 - 14. Northern and western blot analysis detected about a 30% reduction in expression in retinas from heterozygous mice. (J:141780)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prpf3 Mutation:  25 strains or lines available
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
Original:  J:141780 Graziotto JJ, et al., Decreased levels of the RNA splicing factor Prpf3 in mice and zebrafish do not cause photoreceptor degeneration. Invest Ophthalmol Vis Sci. 2008 Sep;49(9):3830-8
All:  2 reference(s)

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MGI 6.11
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