Limk2^{Gt(OST80053)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Limk2^{Gt(OST80053)Lex}
• Name: LIM domain kinase 2; gene trap OST80053, Lexicon Genetics
• MGI ID: MGI:4176477
• Gene: Limk2 Location: Chr11:3294256-3359189 bp, - strand Genetic Position: Chr11, 2.34 cM
• Alliance: Limk2^{Gt(OST80053)Lex} page

Open eyelids at birth in Limk2^{Gt(OST80053)Lex}/Limk2^{Gt(OST80053)Lex} mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: OST80053
• Germline Transmission: Earliest citation of germline transmission: J:192231
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector inserted into intron 12. Western blot analysis confirmed the absence of protein expression in the spleen, brain, lung and retina. (J:192231)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST80053	CG518476 ; (MGI Seq Detail)	3' RACE	Chr11:3295590-3297696 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  88 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Generation of the Limk2^{Gt(OST80053)Lex} allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Limk2 Mutation: 74 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 4 reference(s)