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Del(10Mcm9-Asf1a)1Byg
Gene trapped Allele Detail
Summary
Symbol: Del(10Mcm9-Asf1a)1Byg
Name: gene trap XE518 induced deletion 1, BayGenomics
MGI ID: MGI:4126239
Synonyms: Mcm9/Asf1aGt(XE518)Byg, Mcm9XE518, XE
Gene: Del(10Mcm9-Asf1a)1Byg  Location: Chr10:53472696-53496109 bp  Genetic Position: Chr10, Syntenic
Del(10Mcm9-Asf1a)1Byg/Del(10Mcm9-Asf1a)1Byg embryos are developmentally arrested at E8.5

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Mutant Cell Line:  XE518
Germline Transmission:  Earliest citation of germline transmission: J:177420
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout)
Mutations:    Insertion of gene trap vector, Intergenic deletion, Intragenic deletion     Vector: pGT1Lxf     Vector Type: gene trap
  Del(10Mcm9-Asf1a)1Byg involves 2 genes/genome features (Mcm9, Asf1a) View all
 
Mutation detailsThe gene trap vector inserted in intron 4 of Mcm9 causing a deletion downstream of exon 4 including all of Asf1a. RT-PCR confirmed the absence of mRNA for both Asf1a and Mcm9 in homozygous embryos. (J:177420)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Schematic of the insertion sites of the Asf1aGt(AL0673)Wtsi, Del(10Mcm9-Asf1a)1Byg, Mcm9Gt(AW0655)Wtsi, and Mcm9Gt(XG743)Byg gene traps
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Del(10Mcm9-Asf1a)1Byg
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(10Mcm9-Asf1a)1Byg Mutation:  0 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory