Tg(AAVS1)A1Xob
Transgene Detail

Summary

• Symbol: Tg(AAVS1)A1Xob
• Name: transgene insertion A1, Xandra Breakefield
• MGI ID: MGI:3852016
• Synonyms: AAVS1 transgenic mice (founder line A1)
• Transgene: Tg(AAVS1)A1Xob Location: unknown
• Alliance: Tg(AAVS1)A1Xob page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: An 8.2 kb human genomic fragment containing the entire adeno-associated virus integration site 1 (AAVS1) locus was isolated after EcoRI digestion of plasmid pRIA-N3. Transgenic founder line A1 was established and found to have approximately 5 copies of the transgene integrated at a single locus. (J:150852)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:150852 Bakowska JC, et al., Targeted transgene integration into transgenic mouse fibroblasts carrying the full-length human AAVS1 locus mediated by HSV/AAV rep(+) hybrid amplicon vector. Gene Ther. 2003 Sep;10(19):1691-702
• All: 3 reference(s)