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HrHp
Chemically induced Allele Detail
Nomenclature
Symbol: HrHp
Name: hairless; hairpoor
MGI ID: MGI:3851914
Gene: Hr  Location: Chr14:70552212-70573548 bp, + strand  Genetic Position: Chr14, 36.32 cM
Hair coat abnormalities in HrHp/Hr+ and HrHp/HrHp mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  BALB/cJ
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsENU induced a T to A transversion at position 403 in noncoding exon 2. This mutation changes the initiation methionine codon ATG to AAG and abolishes translation of the upstream open reading frame. (J:150720)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hr Mutation:  57 strains or lines available
References
Original:  J:150720 Baek IC, et al., A novel mutation in Hr causes abnormal hair follicle morphogenesis in hairpoor mouse, an animal model for Marie Unna Hereditary Hypotrichosis. Mamm Genome. 2009 Jun;20(6):350-8
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory