About   Help   FAQ
Targeted Allele Detail
Symbol: Cngb1tm1Sjpi
Name: cyclic nucleotide gated channel beta 1; targeted mutation 1, Steven J Pittler
MGI ID: MGI:3851598
Synonyms: Cngb1-X1 KO
Gene: Cngb1  Location: Chr8:95239045-95306585 bp, - strand  Genetic Position: Chr8, 47.12 cM
Germline Transmission:  Earliest citation of germline transmission: J:150504
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment including exons 1 and 2 was replaced with a pgk-neo cassette via homologous recombination. Northern blot analysis confirmed the absence of RNA expression in homozygous mice. Western blot analysis confirmed the absence of protein expression in rod outer segments from homozygous mice. (J:150504)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cngb1 Mutation:  32 strains or lines available
Original:  J:150504 Zhang Y, et al., Knockout of GARPs and the beta-subunit of the rod cGMP-gated channel disrupts disk morphogenesis and rod outer segment structural integrity. J Cell Sci. 2009 Apr 15;122(Pt 8):1192-200
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.12
The Jackson Laboratory