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Tg(Scn1a*)RH9Aesc
Transgene Detail
Nomenclature
Symbol: Tg(Scn1a*)RH9Aesc
Name: transgene insertion RH9, Andrew Escayg
MGI ID: MGI:3851210
Synonyms: Scn1aTg-RH9
Transgene: Tg(Scn1a*)RH9Aesc  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/NJ
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Scn1a*)RH9Aesc expresses 1 gene
 
Mutation detailsA BAC (clone 259E13) of size 187 kb containing mouse genomic sequence extending from 115 kb upstream of the Scn1a translation start site to 3 kb downstream from the polyA termination signal was modified to add a FLAG tag, an E954Q substitution (confering TTX and STX resistance), and an R1648H substitution (homologous to a mutation seen in human patients with Generalized Epilepsy with Febrile Seizures Plus). Two lines were generated, RH5 and RH9. Line RH9 had the highest level of transgene expression. (J:150454)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:150454 Tang B, et al., A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation. Neurobiol Dis. 2009 Jul;35(1):91-102
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory