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Targeted Allele Detail
Symbol: Trim63tm2.1Vlcg
Name: tripartite motif-containing 63; targeted mutation 2.1, Velocigene
MGI ID: MGI:3851102
Synonyms: deltaR-MuRF1myc
Gene: Trim63  Location: Chr4:134315122-134329628 bp, + strand  Genetic Position: Chr4, 66.58 cM
Germline Transmission:  Earliest citation of germline transmission: J:150424
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 and 2 were replaced with a cDNA for those alleles lacking the coding region for the ring finger. A downstream floxed neo cassette was removed by transient cre expression. (J:150424)
Strategy for the generation of the Trim63tm2.1Vlcg allele
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trim63 Mutation:  7 strains or lines available
Original:  J:150424 Cohen S, et al., During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation. J Cell Biol. 2009 Jun 15;185(6):1083-95
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory