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Trim63tm2.1Vlcg
Targeted Allele Detail
Nomenclature
Symbol: Trim63tm2.1Vlcg
Name: tripartite motif-containing 63; targeted mutation 2.1, Velocigene
MGI ID: MGI:3851102
Synonyms: deltaR-MuRF1myc
Gene: Trim63  Location: Chr4:134315122-134329628 bp, + strand  Genetic Position: Chr4, 66.58 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:150424
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 and 2 were replaced with a cDNA for those alleles lacking the coding region for the ring finger. A downstream floxed neo cassette was removed by transient cre expression. (J:150424)
Strategy for the generation of the Trim63tm2.1Vlcg allele
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trim63 Mutation:  7 strains or lines available
References
Original:  J:150424 Cohen S, et al., During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation. J Cell Biol. 2009 Jun 15;185(6):1083-95
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory