Cul4a^tm1.1Pz
Targeted Allele Detail

Summary

• Symbol: Cul4a^tm1.1Pz
• Name: cullin 4A; targeted mutation 1.1, Pengbo Zhou
• MGI ID: MGI:3851024
• Synonyms: Cul4a^fl
• Gene: Cul4a Location: Chr8:13155623-13197940 bp, + strand Genetic Position: Chr8, 5.73 cM
• Alliance: Cul4a^tm1.1Pz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150427
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 17-19, which span the essential cullin homology domain and neddylation site, were floxed by homologous recombination. A loxP site and a FRT-flanked neomycin cassette were inserted 1.1kb upstream of exon 17 with an additional loxP site inserted 300 bp downstream of exon 19. The neo cassette was subsequently removed by crossing founder mice with FLPe transgenic mice. (J:150427)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cul4a Mutation: 30 strains or lines available

References

• Original: J:150427 Liu L, et al., CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis. Mol Cell. 2009 May 14;34(4):451-60
• All: 3 reference(s)