Tg(HLA-B*0702/H2-K^b)#Sette
Transgene Detail

Summary

• Symbol: Tg(HLA-B*0702/H2-K^b)#Sette
• Name: transgene insertion, Alessandro Sette
• MGI ID: MGI:3851011
• Synonyms: B0702 transgenic, B7.2^tg, HLA-B*0702, HLA-B7
• Transgene: Tg(HLA-B*0702/H2-K^b)#Sette Location: unknown
• Alliance: Tg(HLA-B*0702/H2-K^b)#Sette page

Transgene origin

• Strain of Origin: BALB/c x C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The model was created by microinjecting a chimeric transgene combining a fragment of the genomic clone of the human HLA-B*0702 gene that included leader sequence, alpha1 and alpha2 domains ligated to a fragment of the murine H2-K^b gene containing the alpha3, transmembrane and cytoplasmic domains. (J:150564)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:150564 Alexander J, et al., Derivation of HLA-B*0702 transgenic mice: functional CTL repertoire and recognition of human B*0702-restricted CTL epitopes. Hum Immunol. 2003 Feb;64(2):211-23
• All: 7 reference(s)