Tg(HLA-A2*/H2-Kb)273Rtct
Transgene Detail

Summary

• Symbol: Tg(HLA-A2*/H2-Kb)273Rtct
• Name: transgene insertion 273, Robert Chesnut
• MGI ID: MGI:3851006
• Synonyms: A2.1/K^b, A2/K^b, HLA-A*0201/K^b, HLA-A2, HLA-A2.1/K^b
• Transgene: Tg(HLA-A2*/H2-Kb)273Rtct Location: unknown
• Alliance: Tg(HLA-A2*/H2-Kb)273Rtct page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The model was created by microinjecting a chimeric transgene combining a fragment of the genomic clone of the human HLA-A*0201 gene that included leader sequence, alpha1 and alpha2 domains ligated to a fragment of the murine H2-K^b gene containing the alpha3, transmembrane and cytoplasmic domains. (J:108157)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:108157 Vitiello A, et al., Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex. J Exp Med. 1991 Apr 1;173(4):1007-15
• All: 10 reference(s)