Ppm1k^tm1Yiwa
Targeted Allele Detail

Summary

• Symbol: Ppm1k^tm1Yiwa
• Name: protein phosphatase 1K (PP2C domain containing); targeted mutation 1, Yibin Wang
• MGI ID: MGI:3850971
• Synonyms: PP2Cm^-
• Gene: Ppm1k Location: Chr6:57483487-57512453 bp, - strand Genetic Position: Chr6, 27.82 cM
• Alliance: Ppm1k^tm1Yiwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150451
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: The coding sequence of exon 2 was replaced with a nuclear localized lacZ gene and neo cassette. The absence of protein expression was confirmed by western blot analysis on heart extract. (J:150451)

Generation of the Ppm1k^tm1Yiwa allele

Disease models

Expression

In Mice Carrying this Mutation:	53 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppm1k Mutation: 30 strains or lines available

References

• Original: J:150451 Lu G, et al., Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells. J Clin Invest. 2009 Jun;119(6):1678-87
• All: 15 reference(s)