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Tg(Acta2-RAC1*G12V)33Pjgc
Transgene Detail
Nomenclature
Symbol: Tg(Acta2-RAC1*G12V)33Pjgc
Name: transgene insertion 33, Pascal J Goldschmidt-Clermont
MGI ID: MGI:3850849
Synonyms: RacCA
Transgene: Tg(Acta2-RAC1*G12V)33Pjgc  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Acta2-RAC1*G12V)33Pjgc expresses 1 gene
 
Mutation detailsThe cDNA coding for human RAC1 was mutated with a glycine 12 to valine substitution. The cDNA of RacCA, including its polyadenylation tail, was cloned within the Smp-8 plasmid that contained a 3.6 kb segment of the 5 kb-region of SMA promoter. The SMA promoter was used to induce selective overexpression of RacCA in SMCs. The purified fragment was microinjectedinto fertilized mouse eggs from FVB/N females, (J:150479)
Phenotypes
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Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:150479 Hassanain HH, et al., Hypertension caused by transgenic overexpression of Rac1. Antioxid Redox Signal. 2007 Jan;9(1):91-100
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory