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Smad9tm3Jfm
Targeted Allele Detail
Nomenclature
Symbol: Smad9tm3Jfm
Name: SMAD family member 9; targeted mutation 3, James F Martin
MGI ID: MGI:3850120
Synonyms: Smad8lacZ
Gene: Smad9  Location: Chr3:54755582-54801257 bp, + strand  Genetic Position: Chr3, 25.62 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:150213
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES-lacZ and floxed pgk-neo cassette was inserted into exon 4 via homologous recombination. Immunostaining analysis confirmed the absence of endogenous protein and presence of LacZ expression in prostates from homozygous mice. (J:150213)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad9 Mutation:  18 strains or lines available
References
Original:  J:150213 Huang Z, et al., Defective pulmonary vascular remodeling in Smad8 mutant mice. Hum Mol Genet. 2009 Aug 1;18(15):2791-801
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory