About   Help   FAQ
Smad9tm3Jfm
Targeted Allele Detail
Summary
Symbol: Smad9tm3Jfm
Name: SMAD family member 9; targeted mutation 3, James F Martin
MGI ID: MGI:3850120
Synonyms: Smad8lacZ
Gene: Smad9  Location: Chr3:54663003-54708678 bp, + strand  Genetic Position: Chr3, 25.62 cM, cytoband D
Alliance: Smad9tm3Jfm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:150213
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES-lacZ and floxed pgk-neo cassette was inserted into exon 4 via homologous recombination. Immunostaining analysis confirmed the absence of endogenous protein and presence of LacZ expression in prostates from homozygous mice. (J:150213)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad9 Mutation:  32 strains or lines available
References
Original:  J:150213 Huang Z, et al., Defective pulmonary vascular remodeling in Smad8 mutant mice. Hum Mol Genet. 2009 Aug 1;18(15):2791-801
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory