Tg(Myh6-PTGS2)17Upme
Transgene Detail

Summary

• Symbol: Tg(Myh6-PTGS2)17Upme
• Name: transgene insertion 17, Marta Casado
• MGI ID: MGI:3850105
• Synonyms: TgCOX-2, Tg(MHC-PTGS2)17Upme
• Transgene: Tg(Myh6-PTGS2)17Upme Location: unknown
• Alliance: Tg(Myh6-PTGS2)17Upme page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-PTGS2)17Upme expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PTGS2 (5743)

  Ptgs2

  (MGI:97798)

• Mutation details: The mouse cardiac alpha-myosin heavy chain promoter (Myh6) drives the expression of a human PTGS2 (COX-2) gene including 5' UTR region. The poly (A) signal sequences of human growth hormone were included at the 3' end of the construct. Three copies of the transgene are present in line 17. In addition to line 17, line 12 was also created. (J:149176)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:149176 Inserte J, et al., Constitutive COX-2 activity in cardiomyocytes confers permanent cardioprotection Constitutive COX-2 expression and cardioprotection. J Mol Cell Cardiol. 2009 Feb;46(2):160-8
• All: 1 reference(s)