Erbin^{Gt(BGA258)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Erbin^{Gt(BGA258)Byg}
• Name: Erbb2 interacting protein; gene trap BGA258, BayGenomics
• MGI ID: MGI:3849991
• Synonyms: erbin^deltaC
• Gene: Erbin Location: Chr13:103955295-104057022 bp, - strand Genetic Position: Chr13, 56.16 cM, cytoband D1
• Alliance: Erbin^{Gt(BGA258)Byg} page

Deficits in myelination and entheathment of axons in Erbin^{Gt(BGA258)Byg}/Erbin^{Gt(BGA258)Byg} mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: BGA258
• Germline Transmission: Earliest citation of germline transmission: J:149996
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: The gene trap vector pGT2LxF, which contains a beta-geo cassette, inserted downstream of exon 20. The predicted fusion protein, containing amino acids 1 through 693, lacks the PDZ domain found in the C-terminus of the endogenous protein. The expression of the fusion protein lacking the PDZ domain was confirmed by western blot analysis on brain extracts. (J:149996)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  BGA258	CW509384 ; (MGI Seq Detail)	5' RACE	Chr13:103975817-103975893 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  2 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Generation of the Erbin^{Gt(BGA258)Byg} allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Erbin Mutation: 61 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:149996 Tao Y, et al., Erbin regulates NRG1 signaling and myelination. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9477-82
• All: 7 reference(s)