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Tg(Lck-Tnfsf14)24Yxf
Transgene Detail
Nomenclature
Symbol: Tg(Lck-Tnfsf14)24Yxf
Name: transgene insertion 24, Yang-Xin Fu
MGI ID: MGI:3849832
Synonyms: Tg(Lck-LIGHT)
Transgene: Tg(Lck-Tnfsf14)24Yxf  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Lck-Tnfsf14)24Yxf expresses 1 gene
 
Mutation detailsTnfsf14 coding sequence was driven by the proximal Lck promoter and human CD2 enhancer with human growth hormone gene (polyadenylation site) included downstream. Lines 24 and 27 in a C57BL/6 background were selected for further investigation with similar phenotypes observed in both lines. Expression in lymphocytes was confirmed by flow cytometry analysis of lymphocytes. (J:129951)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:129951 Wang J, et al., The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT. J Clin Invest. 2001 Dec;108(12):1771-80
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory