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Angptl3tm1Lex
Targeted Allele Detail
Nomenclature
Symbol: Angptl3tm1Lex
Name: angiopoietin-like 3; targeted mutation 1, Lexicon Pharmaceuticals
MGI ID: MGI:3849576
Synonyms: Angptl3-
Gene: Angptl3  Location: Chr4:99030954-99046111 bp, + strand  Genetic Position: Chr4, 45.6 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:149912
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe first 4 exons of the gene were replaced with a lacZ/neomycin cassette. Correct targeting was confirmed by Southern blotting. (J:149912)
Generation of the Angptl3tm1Lex allele
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Angptl3 Mutation:  16 strains or lines available
Notes
See also, data as provided by Lexicon Genetics, Inc.
References
Original:  J:149912 Lee EC, et al., Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL). J Biol Chem. 2009 May 15;284(20):13735-45
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory