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Transgene Detail
Symbol: Tg(CAG-RAB9A)500Repa
Name: transgene insertion 500, Richard E Pagano
MGI ID: MGI:3849445
Synonyms: Rab9TG, Rab9TG
Transgene: Tg(CAG-RAB9A)500Repa  Location: unknown  
Strain of Origin:  (C57BL/6 x CBA)F1 X C57BL/6
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(CAG-RAB9A)500Repa expresses 1 gene
Mutation detailsA transgenic construct containing a HA-tagged human RAB9A, member RAS oncogene family, gene (RAB9A) under the control of the CAG promoter (CAGGS, chicken beta actin promoter/enhancer coupled with the cytomegalovirus immediate-early enhancer), was injected into fertilized (C57BL/6 X CBA)F1 X C57BL/6 mouse eggs. Founder line 500 was subsequently established. Expression is approximately 30-fold higher than endogenous Rab9 protein in the liver. (J:144240)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:144240 Kaptzan T, et al., Development of a Rab9 transgenic mouse and its ability to increase the lifespan of a murine model of Niemann-Pick type C disease. Am J Pathol. 2009 Jan;174(1):14-20
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.04
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