Adra2a^tm1Qiwa
Targeted Allele Detail

Summary

• Symbol: Adra2a^tm1Qiwa
• Name: adrenergic receptor, alpha 2a; targeted mutation 1, Qin Wang
• MGI ID: MGI:3849302
• Synonyms: HA-alpha2AAR, HA alpha2A-AR KI
• Gene: Adra2a Location: Chr19:54033690-54037413 bp, + strand Genetic Position: Chr19, 49.04 cM
• Alliance: Adra2a^tm1Qiwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149752
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

Allele Type: Targeted Mutation: Insertion Mutation details: The coding region was replaced with one that contained a 5' hemagglutinin (HA) epitope tag and was followed by a floxed neo cassette. Germ line, cre mediated recombination removed the neo cassette. (J:149752)

Generation of the Adra2a^tm1Qiwa allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adra2a Mutation: 23 strains or lines available

References

• Original: J:149752 Lu R, et al., Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is because of ligand-selective internalization. J Biol Chem. 2009 May 8;284(19):13233-43
• All: 5 reference(s)