About   Help   FAQ
Fmn1tm2Made
Targeted Allele Detail
Nomenclature
Symbol: Fmn1tm2Made
Name: formin 1; targeted mutation 2, Markus Dettenhofer
MGI ID: MGI:3848983
Synonyms: Fmn1Pro
Gene: Fmn1  Location: Chr2:113327736-113716767 bp, + strand  Genetic Position: Chr2, 57.3 cM, cytoband C1-qter
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:149484
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neo cassette was inserted into exon 9. This insertion leads to a disruption at the proline-rich FH1 domain. The absence of protein was confirmed by western blot analysis of embryonic fibroblasts extracts. (J:149484)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 39 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fmn1 Mutation:  6 strains or lines available
References
Original:  J:149484 Zhou F, et al., Formin1 disruption confers oligodactylism and alters Bmp signaling. Hum Mol Genet. 2009 Jul 1;18(13):2472-82
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/07/2020
MGI 6.15
The Jackson Laboratory