Tg(Prnp-FTL*)4Ruvi
Transgene Detail
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Symbol: |
Tg(Prnp-FTL*)4Ruvi |
Name: |
transgene insertion 4, Ruben Vidal |
MGI ID: |
MGI:3848965 |
Synonyms: |
FTL-Tg4, MoPrP-FTL498-499InsTC |
Transgene: |
Tg(Prnp-FTL*)4Ruvi Location: unknown
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Alliance: |
Tg(Prnp-FTL*)4Ruvi page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Prnp-FTL*)4Ruvi expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
FTL (2512) |
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Mutation details: The mouse promoter was used to drive brain and heart specific expression of the human cDNA with TC insertions at the cDNA positions 498 and 499, respectively. This insertion leads to a frame-shift that alters the last 9 amino acids of the C-terminus and adds 16 additional amino acids. Four lines were created (lines 1, 2, 3, and 4) with 40 to 50, 5 to 10, 1 to 5, and 1 to 5 copies of the transgene, respectively. Line 4 was used for subsequent studies.
(J:131053)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:131053 Vidal R, et al., Expression of a mutant form of the ferritin light chain gene induces neurodegeneration and iron overload in transgenic mice. J Neurosci. 2008 Jan 2;28(1):60-7 |
All: |
3 reference(s) |
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