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Transgene Detail
Symbol: Tg(Prnp-FTL*)4Ruvi
Name: transgene insertion 4, Ruben Vidal
MGI ID: MGI:3848965
Synonyms: FTL-Tg4, MoPrP-FTL498-499InsTC
Transgene: Tg(Prnp-FTL*)4Ruvi  Location: unknown  
Strain of Origin:  C3HeB/FeJ
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Prnp-FTL*)4Ruvi expresses 1 gene
Mutation detailsThe mouse promoter was used to drive brain and heart specific expression of the human cDNA with TC insertions at the cDNA positions 498 and 499, respectively. This insertion leads to a frame-shift that alters the last 9 amino acids of the C-terminus and adds 16 additional amino acids. Four lines were created (lines 1, 2, 3, and 4) with 40 to 50, 5 to 10, 1 to 5, and 1 to 5 copies of the transgene, respectively. Line 4 was used for subsequent studies. (J:131053)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:131053 Vidal R, et al., Expression of a mutant form of the ferritin light chain gene induces neurodegeneration and iron overload in transgenic mice. J Neurosci. 2008 Jan 2;28(1):60-7
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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