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Plxnd1tm1.1Tmj
Targeted Allele Detail
Nomenclature
Symbol: Plxnd1tm1.1Tmj
Name: plexin D1; targeted mutation 1.1, Thomas M Jessell
MGI ID: MGI:3848812
Synonyms: plexinD1flox, Plxnd1flox/flox
Gene: Plxnd1  Location: Chr6:115954811-115995005 bp, - strand  Genetic Position: Chr6, 53.72 cM
Increase in extraretinal vascular outgrowth in ischemic Plxnd1tm1.1Tmj/Plxnd1tm1Ddg Tg(CAG-cre/Esr1*)1Egwa/0 retinas

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:143763
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn frt flanked neo cassette with a loxP site was inserted upstream of exon 1 and an additional loxP site was inserted downstream of exon 1. Germ line, flp mediated recombination removed the neo cassette leaving exon 1 floxed. (J:143763)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Plxnd1 Mutation:  7 strains or lines available
References
Original:  J:143763 Zhang Y, et al., Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects. Dev Biol. 2009 Jan 1;325(1):82-93
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory