Itgb1tm5.1Ref
Targeted Allele Detail
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Symbol: |
Itgb1tm5.1Ref |
Name: |
integrin beta 1 (fibronectin receptor beta); targeted mutation 5.1, Reinhard Fassler |
MGI ID: |
MGI:3848527 |
Synonyms: |
hpmKIlox |
Gene: |
Itgb1 Location: Chr8:129412135-129459681 bp, + strand Genetic Position: Chr8, 76.09 cM, cytoband E2
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Alliance: |
Itgb1tm5.1Ref page
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Hair and skin phenotypes of various keratinocyte conditional Itgb1 alleles
Show the 4 phenotype image(s) involving this allele.
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: A 141 bp cDNA fragment of the mouse Itgb1 gene encoding for the entire cytoplasmic tail including the stop codon was inserted in frame into exon 15 and a floxed neo-tk cassette was inserted into intron 15 via homologous recombination. Cre mediated recombination then removed the neo-tk cassette leaving a single loxP site in intron 15. Analysis indicated that the mutant mRNA undergoes nonsense mediated decay.
(J:148885)
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Generation of the Itgb1tm5.1Ref allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Itgb1 Mutation: |
59 strains or lines available
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Original: |
J:148885 Piwko-Czuchra A, et al., Beta1 integrin-mediated adhesion signalling is essential for epidermal progenitor cell expansion. PLoS One. 2009;4(5):e5488 |
All: |
3 reference(s) |
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