Irak2^tm1Jth
Targeted Allele Detail

Summary

• Symbol: Irak2^tm1Jth
• Name: interleukin-1 receptor-associated kinase 2; targeted mutation 1, James A Thomas
• MGI ID: MGI:3848359
• Gene: Irak2 Location: Chr6:113615428-113671987 bp, + strand Genetic Position: Chr6, 52.82 cM
• Alliance: Irak2^tm1Jth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149258
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exon 1 was replaced with a neo cassette. The absence of transcript expression was confirmed by northern blot analysis on R848 treated macrophages. (J:149258)

Generation of the Irak2^tm1Jth allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irak2 Mutation: 58 strains or lines available

References

• Original: J:149258 Wan Y, et al., Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control. J Biol Chem. 2009 Apr 17;284(16):10367-75
• All: 3 reference(s)